Clinical study of keratocystic odontogenic tumors

Keratocystic Odontogenic Tumors – Clinical and Molecular Features

Keratocystic odontogenic tumors (KCOTs) are certainly among the most studied lesions in oral pathology, which is not a surprise considering their perplexing clinical behavior and complicated mechanism of pathogenesis. In fact, the specific KCOT features are the reason for numerous discussions regarding the true nature and classification of these lesions, which are still debated in the scientifi...

Smoothened gene alterations in keratocystic odontogenic tumors

BACKGROUND It has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of the skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs. METHODS Polymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain-termination sequencing we...

Li Gene Alterations in Keratocystic Odontogenic Tumors

Endoscopic resection of maxillary sinus keratocystic odontogenic tumors.

INTRODUCTION Modified endoscopic approaches allow for complete excision of maxillary keratocystic odontogenic tumors (KCOTs), with significantly decreased morbidity compared to open approaches. Formerly odontogenic keratocysts, KCOTs were reclassified by the World Health Organization in 2005 due to their aggressive and locally destructive nature. These tumors arise from the dental lamina or bas...

Conservative Management of Keratocystic Odontogenic Tumors of Jaws

PURPOSE The aim of this study was to evaluate different surgical treatment methods for keratocystic odontogenic tumors (KCOTs) and the outcome of those treatments over a 9-year period. PATIENTS AND METHODS A retrospective review was performed on 43 KCOTs in 39 patients. In radiographic evaluations for diagnosis, follow ups and before and after treatment, panoramic, 3D CT and MR images were us...